The Headache: The Science of a Most Confounding Affliction-and a Search for Relief

"Required reading for anyone with a head."-Mary Roach, New York Times bestselling author of Stiff and Fuzz

"[The Headache] weaves together history, biology, a survey of current research, testimony from patients, and an agonizing account of Zeller's own suffering. . . If there's a lesson here, it's that pain resists mastery, but understanding, however incomplete, can offer its own form of relief."-New Yorker

From blinding migraines to severe headache disorders known as "clusters," chronic head pain affects 40% of the population, many of them suffering in silence. Finally, The Headache reveals the science behind a group of disorders that is as much a curse as a cultural punchline, and leads to key insights into the nature of pain itself.

Guided by his own decades-long struggle with cluster headaches, veteran science journalist Tom Zeller Jr.'s journey into headache science is at once intimate and panoramic. He visits cutting-edge clinics; interviews dozens of doctors, neurologists, and fellow headache patients; participates in clinical trials for multi-million-dollar new medicines; and even experiments with psilocybin in search of relief.

Along the way, Zeller traces the longer arc of mystery around headaches, from prehistoric skull surgery to Virginia Woolf's assertion that, in the throes of a migraine, "language runs dry," to reveal how headaches became one of the most under-researched afflictions in medicine-and how that is slowly starting to change.

With warmth, wit, and infectious curiosity, Zeller's search for the origins of his own headaches becomes a journey into the inner workings of the human nervous system, and an invaluable witness to one of the most maligned conditions known to medicine.

Hardback | 336 pages | Published August 2025